Table of Contents
What is the action of adrenergic decongestants?
Activation of al- adrenergic receptors results in vasoconstriction that reduces both the volume of blood in the mucosa and the mucosal volume, leading to decreased nasal congestion. Decongestants contain sympathomimetic agents, that is, drugs that mimic the actions of NE.
How do adrenergic agonists help with nasal congestion?
Pharmacology. The vast majority of decongestants act via enhancing norepinephrine (noradrenaline) and epinephrine (adrenaline) or adrenergic activity by stimulating the α1-adrenergic receptor since they mediate vasoconstriction and constricting nasal vasculature causes decongestion of nasal mucosa.
Why are decongestants behind the counter?
Because, pseudoephedrine can be used to illegally manufacture methamphetamines (also known as meth), federal regulations require that it be sold behind the pharmacy or service counter. A prescription is not required to purchase these products.
Why are alpha agonists used as nasal decongestants?
In conclusion, a selective alpha(2)-adrenoceptor agonist causing constriction preferentially in the large venous sinusoids and veins of nasal mucosa and producing nasal decongestion is expected to show efficacy in the treatment of nasal congestion without the characteristic arterio-constrictor action of the standard …
What are side effects of decongestants?
Side effects of decongestants
- feeling sleepy (look for non-drowsy medicines)
- irritation of the lining of your nose.
- headaches.
- feeling or being sick.
- a dry mouth.
- feeling restless or agitated.
- a rash.
What is the best decongestant?
Our picks
- Benadryl Allergy Plus Congestion Ultratabs.
- Best OTC sinus decongestant for a headache. Advil Sinus Congestion and Pain.
- Afrin No-Drip Severe Congestion.
- Little Remedies Decongestant Nose Drops.
- Sudafed PE Day and Night Sinus Pressure Tablets.
- Cabinet Nasal Decongestant Tablets.
- Mucinex Nightshift Cold and Flu Liquid.
What is a good decongestant for ears?
Pseudoephedrine is used to relieve nasal or sinus congestion caused by the common cold, sinusitis, and hay fever and other respiratory allergies. It is also used to relieve ear congestion caused by ear inflammation or infection.
What is the safest decongestant?
In the drug realm, antihistamines such as diphenhydramine (Benadryl), chlorpheniramine (Chlor-Trimeton), cetirizine (Zyrtec), and loratadine (Claritin) can help with a stuffy nose are safe for the heart.
What is the most effective decongestant?
What receptor can relieve nasal congestion?
Decongestants. Decongestants produce vasoconstriction within the nasal mucosa through α-adrenergic receptor activation and therefore are effective in relieving the symptoms of nasal obstruction.
What happens if you take decongestants for too long?
The longer you use a spray decongestant, the more likely you are to get the rebound phenomenon. It can lead to chronic sinusitis and other serious, long-term problems. Give your doctor a call if you’re having any of these issues: It’s all in your nose.
How long is it safe to take decongestants?
Decongestants should only be used for a short time, usually less than 10 days. If you take them for longer, you’re more likely to get side effects. Only take pseudoephedrine for longer than 10 days if a doctor has said it’s OK.