Table of Contents
What drugs are used in thrombolytic therapy?
The most commonly used clot-busting drugs — also known as thrombolytic agents — include:
- Eminase (anistreplase)
- Retavase (reteplase)
- Streptase (streptokinase, kabikinase)
- t-PA (class of drugs that includes Activase)
- TNKase (tenecteplase)
- Abbokinase, Kinlytic (rokinase)
What are the side effects of thrombolytic therapy?
The side effects associated with thrombolytics include:
- Major bleeding in the brain.
- Kidney damage in patients with kidney disease.
- Severe hypertension (high blood pressure)
- Severe blood loss or internal bleeding.
- Bruising or bleeding at the site of thrombolysis.
- Damage to the blood vessels.
Who is eligible for thrombolytic therapy?
Onset of symptoms less than three hours before beginning treatment. No head trauma or prior stroke in the past three months. No heart attack (myocardial infarction) in the past three months. No gastrointestinal or genitourinary hemorrhage in the past 21 days.
When should thrombolytic therapy not be used?
Absolute Contraindications for Thrombolytic Treatment
- Recent intracranial hemorrhage (ICH)
- Structural cerebral vascular lesion.
- Intracranial neoplasm.
- Ischemic stroke within three months.
- Possible aortic dissection.
- Active bleeding or bleeding diathesis (excluding menses)
Is aspirin a thrombolytic drug?
Thrombolytic, antiplatelet (e.g., aspirin), and antithrombin (e.g., heparin) agents should be discontinued, and reversal of heparin with protamine (1 mg of protamine per 100 U of heparin) should be considered.
How long does it take for thrombolytic therapy to work?
Thrombolysis can break down and disperse a clot that is preventing blood from reaching your brain. For most people thrombolysis needs to be given within four and a half hours of your stroke symptoms starting. In some circumstances, your doctor may decide that it could still be of benefit within six hours.
When do you start thrombolytic therapy?
For most people thrombolysis needs to be given within four and a half hours of your stroke symptoms starting. In some circumstances, your doctor may decide that it could still be of benefit within six hours. However, the more time that passes, the less effective thrombolysis will be.
What is the best medicine for heart?
The Big 6 Heart Medications
- Statins — to lower LDL cholesterol.
- Aspirin — to prevent blood clots.
- Clopidogrel — to prevent blood clots.
- Warfarin — to prevent blood clots.
- Beta-blockers — to treat heart attack and heart failure and sometimes used to lower blood pressure.
Are there side effects for thrombolytic therapy?
Blood in the urine
What are potential complications of thrombolytic therapy?
However, thrombolytic therapy with rtPA can be associated with a number of complications. Many of the rtPArelated complications result from its thrombolytic action including bleeding (intracerebral and systemic haemorrhage), reperfusion injury with oedema, and angioedema.
What are the contraindications for thrombolytics?
Precautions. Bleeding is the major complication of thrombolytic therapy. Consequently, absolute contraindications include dissecting aortic aneurysm, pericarditis, stroke, or neurosurgical procedures within 6 months or known intracranial neoplasm. Relative contraindications include major surgery or bleeding within 6 weeks,…
What is intra-arterial thrombolytic therapy?
What is intra-arterial thrombolytic therapy? Intra-arterial thrombolytic therapy is a method for delivering clot-busting medication , usually tissue plasminogen activator (tPA), using a catheter placed directly into the artery near the clot.