Table of Contents
What is haptoglobin test used for?
Haptoglobin testing is used primarily to help detect and evaluate hemolytic anemia and to distinguish it from anemia due to other causes. Testing is used to help determine whether red blood cells (RBCs) are breaking apart or being destroyed prematurely.
Is haptoglobin high or low in hemolytic anemia?
Haptoglobin is an acute-phase reactant whose principal clinical utility is in defining conditions of hemolysis. levels can also become elevated in infection and inflammation. In hemolytic anemia, lactic dehydrogenase (LDH) levels typically increase while haptoglobin levels decrease.
What color is hemoglobin tube?
Specimen required: 2 mL EDTA lavender-top tube with minimum 1.6 mL whole blood.
What does low haptoglobin indicate?
If you have a level that’s lower than 45 milligrams of haptoglobin per deciliter of blood, it’s likely that your red blood cells are being destroyed more quickly than they’re being made. If your level is below the normal range, you may have hemolytic anemia or some other form of anemia.
What is a normal haptoglobin?
The normal range is 41 to 165 milligrams per deciliter (mg/dL) or 410 to 1,650 milligrams per liter (mg/L). Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples.
What is the normal level for haptoglobin?
The normal range is 41 to 165 milligrams per deciliter (mg/dL) or 410 to 1,650 milligrams per liter (mg/L). Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your provider about the meaning of your specific test results.
Why is haptoglobin increased in inflammation?
Haptoglobin, an inflammation-inducible plasma protein Sterile tissue injury or infection initiates a local inflammatory response that mobilizes a systemic acute phase reaction resulting in, among other things, the induction of genes encoding the acute phase plasma proteins (APPs).
Is haptoglobin low in liver disease?
Abstract. Serum haptoglobin levels have been measured in 115 cases of widely differing liver disease. Although low levels were found in some cases of cirrhosis and a number of patients with obstructive jaundice had increased levels, 70% of the values fell within the normal range.
What happens to haptoglobin in hemolysis?
In intravascular hemolysis, free hemoglobin will be released into circulation and hence haptoglobin will bind the hemoglobin. This causes a decline in haptoglobin levels.